Monkey embryos containing human cells are made during a laboratory, a study has confirmed.
The research, by a US-Chinese team, has sparked fresh debate into the ethics of such experiments.
The scientists injected human stem cells – cells that can develop into many different body tissues – into macaque embryos.
The developing embryos were studied for up to 20 days.
Other so-called mixed-species embryos, or chimeras, have been produced in the past, with human cells implanted into sheep and pig embryos.
The scientists were led by Prof Juan Carlos Izpisua Belmonte of the Salk Institute in the US, who, in 2017, helped make the first human-pig hybrid.
Their work could pave the way in addressing the severe shortage of transplantable organs also help understand more about early human development, disease progression, and aging, he said.
“These chimeric approaches might be very useful for advancing biomedical research not just at the very earliest stage of life, but also the newest stage of life.”
He maintained that the study, published in the journal Cell, had met the current ethical and legal guidelines.
“Ultimately, we conduct these studies to know and improve human health,” he said.
Some scientists have, however, raised concerns about the experiment, arguing that while the embryos, in this case, were destroyed at 20 days, others could try to take the work further.
They are calling for a debate over the implications of taking part in human/part nonhuman chimeras.
Commenting on the research, Dr. Anna Smajdor, lecturer and researcher in biomedical ethics at the University of East Anglia’s Norwich Medical School, said it posed “significant ethical and legal challenges”.
She added: “The scientists behind this research state that these chimeric embryos offer new opportunities, because ‘we are unable to conduct certain sorts of experiments in humans’. But whether these embryos are human or not is the hospitable question.”
Prof Julian Savulescu, director of the Oxford Uehiro Centre for Practical Ethics and co-director of the Wellcome Centre for Ethics and Humanities, University of Oxford, said the research “opens Pandora’s box to human-nonhuman chimeras”.
He added: “These embryos were destroyed at 20 days of development but it’s only a matter of your time before human-nonhuman chimeras are successfully developed, perhaps as a source of organs for humans. That is one among the long-term goals of this research.”
Sarah Norcross, director of the Progress Educational Trust, said that while “substantial advances” are being made in the embryo and somatic cell research, which could bring equally substantial benefits, “there is a clear need for ventilation and debate about the moral and regulatory challenges raised”.